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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/32554

Title: Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp isolated from Euphorbia characias
Authors: Magán, Rosa
Marín Sánchez, Clotilde
Barrerra-Pérez, Mario
Rosales Lombardo, María José
Sánchez-Moreno, Manuel
Issue Date: 2004
Abstract: There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II), and another with Ru(III)] against promastigotes of Phytomonas sp. isolated from Euphorbia characias. The incorporation of radiolabelled precursors, ultrastructural alterations and changes in the pattern of metabolite excretion were examined. Different degrees of toxicity were found for each complex: the platinun compound showed an inhibition effect on nucleic acid synthesis, provoking alterations on the levels of mitochondria, nucleus and glycosomes. These results, together with others reported previously in our laboratory about the activity of pyrimidine derivatives, reflect the potential of these compounds as agents in the treatment of Phytomonas sp.
Sponsorship: Financial support Universidad de Granada (Spain), grant BIO 2000-1429.
Publisher: Instituto Oswaldo Cruz
Keywords: Phytomonas sp
Triazolo-pyrimidine complexes
Chemotherapeutic agents
URI: http://hdl.handle.net/10481/32554
ISSN: 0074-0276
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Magán, R.; et al. Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp isolated from Euphorbia characias. Memórias do Instituto Oswaldo Cruz, 99(6): 651-656 (2004). [http://hdl.handle.net/10481/32554]
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