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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/32044

Title: Leishmanicidal activity of nine novel flavonoids from delphinim staphisagria
Authors: Ramírez-Macias, Inmaculada
Marín Sánchez, Clotilde
Díaz, Jesús G.
Rosales Lombardo, María José
Gutiérrez-Sánchez, Ramón
Sánchez-Moreno, Manuel
Issue Date: 2012
Abstract: Objectives. To evaluate the in vitro leishmanicidal activity of nine flavonoid derivatives from Delphinium staphisagria against L. infantum and L. braziliensis. Design and Methods. The in vitro activity of compounds 1–9 was assayed on extracellular promastigote and axenic amastigote forms and on intracellular amastigote forms of the parasites. Infectivity and cytotoxicity tests were carried on J774.2 macrophage cells using Glucantime as the reference drug. The mechanisms of action were analysed performing metabolite excretion and transmission electronic microscope ultrastructural alteration studies. Results. Nine flavonoids showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania infantum and L. braziliensis. These compounds were nontoxic to mammalian cells and were effective at similar concentrations up to or lower than that of the reference drug (Glucantime). The results showed that 2" -acetylpetiolaroside (compound 8) was clearly the most active. Conclusion. This study has demonstrated that flavonoid derivatives are active against L. infantum and L. braziliensis.
Sponsorship: This work was financially supported by the Consolider Ingenio Project CSD2010-00065 (Spain).
Publisher: Hindawi Publishing Corporation
Keywords: In-vitro activity
Natural products
Energy metabolism
Cell death
Trypanosomatids
Promastigotes
Infantum
Drugs
URI: http://hdl.handle.net/10481/32044
ISSN: 1537-744X
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Ramírez-Macias, I.; et al. Leishmanicidal activity of nine novel flavonoids from delphinim staphisagria. Scientific World Journal, 2012: 203646 (2012). [http://hdl.handle.net/10481/32044]
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