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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/32039

Title: Effect of aspirin on cell growth of human MG-63 osteosarcoma life
Authors: Luna-Bertos, María Elvira de
Ramos-Torrecillas, Javier
García-Martínez, Olga
Díaz-Rodríguez, Lourdes
Ruiz-Rodríguez, Concepción
Issue Date: 2012
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in bone tissue repair treatment for their pharmacological action. The objective of this study was to determine the effect of aspirin, on osteoblast growth, using MG63 cell line as osteoblast model. MTT spectrophotometry results showed that 20, 100, and 1000 μM aspirin doses have an inhibitory effect on growth. Cell cycle analysis revealed that aspirin doses of 100 and 1000 μM arrest the cell cycle in phase GO/G1. Parallel apoptosis/necrosis studies showed no changes in comparison to control cells after treatment with 1 or 10 μM aspirin but a significantly increased percentage of cells in apoptosis at doses of 20, 100, and 1000 μM. We highlight that treatment of osteoblast-like cells with 1000 μM aspirin increased not only the percentage of cells in apoptosis but also the percentage of necrotic cells, which was not observed in aspirin treatments at lower doses.
Sponsorship: This study was supported by research group BIO277 (Junta de Andalucía) and by the Department of Nursing of the Health Sciences School of the University of Granada.
Publisher: Hindawi Publishing Corporation
Keywords: Nonsteroidal antiinflammatory drugs
Human osteoblasts
Diclofenac
Bone
Acetaminophen
Ibuprofen
URI: http://hdl.handle.net/10481/32039
ISSN: 1537-744X
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Luna-Bertos, E.; et al. Effect of aspirin on cell growth of human MG-63 osteosarcoma life. Scientific World Journal, 2012: 834246 (2012). [http://hdl.handle.net/10481/32039]
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