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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/31153

Title: The Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performance
Authors: Cuyás, Elisabet
Verdejo-García, Antonio
Fagundo, Ana Beatriz
Khymenets, Olha
Rodríguez, Joan
Cuenca, Aida
Sola Llopis, Susana de
Langohr, Klaus
Peña-Casanova, Jordi
Torrens, Marta
Martín-Santos, Rocío
Farré, Magí
Torre, Rafael de la
Issue Date: 2011
Abstract: This study is aimed to clarify the association between MDMA cumulative use and cognitive dysfunction, and the potential role of candidate genetic polymorphisms in explaining individual differences in the cognitive effects of MDMA. Gene polymorphisms related to reduced serotonin function, poor competency of executive control and memory consolidation systems, and high enzymatic activity linked to bioactivation of MDMA to neurotoxic metabolites may contribute to explain variations in the cognitive impact of MDMA across regular users of this drug. Sixty ecstasy polydrug users, 110 cannabis users and 93 non-drug users were assessed using cognitive measures of Verbal Memory (California Verbal Learning Test, CVLT), Visual Memory (Rey-Osterrieth Complex Figure Test, ROCFT), Semantic Fluency, and Perceptual Attention (Symbol Digit Modalities Test, SDMT). Participants were also genotyped for polymorphisms within the 5HTT, 5HTR2A, COMT, CYP2D6, BDNF, and GRIN2B genes using polymerase chain reaction and TaqMan polymerase assays. Lifetime cumulative MDMA use was significantly associated with poorer performance on visuospatial memory and perceptual attention. Heavy MDMA users (>100 tablets lifetime use) interacted with candidate gene polymorphisms in explaining individual differences in cognitive performance between MDMA users and controls. MDMA users carrying COMT val/val and SERT s/s had poorer performance than paired controls on visuospatial attention and memory, and MDMA users with CYP2D6 ultra-rapid metabolizers performed worse than controls on semantic fluency. Both MDMA lifetime use and gene-related individual differences influence cognitive dysfunction in ecstasy users.
Sponsorship: This study was supported by grants from the National Institutes of Health (NIH) grant no. 1 R01 DA017987, Grant 2005SGR00032, Fondo de Investigaciones Sanitarias (FIS-00/00777), Plan Nacional Sobre Drogas (INT/2012/2002) Spain, Plan Nacional Sobre Drogas: PNSD 2006/101(2007–2009) Spain.
Publisher: Public Library of Science (PLOS)
Keywords: Attention
Cognitive psychology
Drug interactions
Variant genotypes
URI: http://hdl.handle.net/10481/31153
ISSN: 1932-6203
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Cuyás, E.; et al. The Influence of Genetic and Environmental Factors among MDMA Users in Cognitive Performance. Plos One, 6(11): e27206 (2011). [http://hdl.handle.net/10481/31153]
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