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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/31065

Title: The Therapeutic Relationship and Adherence to Antipsychotic Medication in Schizophrenia
Authors: McCabe, Rosemarie
Bullenkamp, Jens
Hansson, Lars
Lauber, Christoph
Martínez Leal, Rafael
Rössler, Wulf
Salize, Hans Joachim
Svensson, Bengt
Torres González, Francisco
Brink, Rob van den
Wiersma, Durk
Priebe, Stefan
Issue Date: 2012
Abstract: [Objective] Previous research has shown that a better therapeutic relationship (TR) predicts more positive attitudes towards antipsychotic medication, but did not address whether it is also linked with actual adherence. This study investigated whether the TR is associated with adherence to antipsychotics in patients with schizophrenia. [Methods] 134 clinicians and 507 of their patients with schizophrenia or a related psychotic disorder participated in a European multi-centre study. A logistic regression model examined how the TR as rated by patients and by clinicians is associated with medication adherence, adjusting for clinician clustering and symptom severity. [Results] Patient and clinician ratings of the TR were weakly inter-correlated (rs = 0.13, p = 0.004), but each was independently linked with better adherence. After adjusting for patient rated TR and symptom severity, each unit increase in clinician rated TR was associated with an increase of the odds ratio of good compliance by 65.9% (95% CI: 34.6% to 104.5%). After adjusting for clinician rated TR and symptom severity, for each unit increase in patient rated TR the odds ratio of good compliance was increased by 20.8% (95% CI: 4.4% to 39.8%). [Conclusions] A better TR is associated with better adherence to medication among patients with schizophrenia. Patients' and clinicians' perspectives of the TR are both important, but may reflect distinct aspects.
Sponsorship: The study was funded by the Research Directorate of the European Commission within Framework Programme 5 (QLG5-CT-2002-01938).
Publisher: Public Library of Science (PLOS)
Keywords: Antipsychotics
Drug therapy
Medical ethics
Medicine and health sciences
Mental health and psychiatry
URI: http://hdl.handle.net/10481/31065
ISSN: 1932-6203
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: McCabe, R.; et al. The Therapeutic Relationship and Adherence to Antipsychotic Medication in Schizophrenia. Plos One, 7(4): e36080 (2012). [http://hdl.handle.net/10481/31065]
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