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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/31038

Title: Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C
Authors: Ruiz Extremera, Ángeles
Muñoz Gámez, José Antonio
Abril-Molina, Ana
Salmerón Ruiz, María Angustias
Muñoz de Rueda, Paloma
Pavón Castillero, Esther José
Quiles-Pérez, Rosa
Carazo, Ángel
Gila, Ana
Jiménez-Ruiz, Sergio
Casado, Jorge
Martín, Ana Belén
Sanjuán-Núñez, Laura
Ocete Hita, Esther
López-Viota Gallardo, Julián
León, Josefa
Salmerón, Javier
Issue Date: 2013
Abstract: This study analyses the evolution of liver disease in women with chronic hepatitis C during the third trimester of pregnancy and the post-partum period, as a natural model of immune modulation and reconstitution. Of the 122 mothers recruited to this study, 89 were HCV-RNA+ve/HIV-ve and 33 were HCV-RNA-ve/HIV-ve/HCVantibody+ve and all were tested during the third trimester of pregnancy, at delivery and post-delivery. The HCV-RNA+ve mothers were categorized as either Type-A (66%), with an increase in ALT levels in the post-partum period (>40 U/L; P<0.001) or as Type-B (34%), with no variation in ALT values. The Type-A mothers also presented a significant decrease in serum HCV-RNA levels in the post-delivery period (P<0.001) and this event was concomitant with an increase in Th1 cytokine levels (INFγ, P = 0.04; IL12, P = 0.01 and IL2, P = 0.01). On the other hand, the Type-B mothers and the HCV-RNA-ve women presented no variations in either of these parameters. However, they did present higher Th1 cytokine levels in the partum period (INFγ and IL2, P<0.05) than both the Type-A and the HCV-RNA-ve women. Cytokine levels at the moment of delivery do not constitute a risk factor associated with HCV vertical transmission. It is concluded that differences in the ALT and HCV-RNA values observed in HCV-RNA+ve women in the postpartum period might be due to different ratios of Th1 cytokine production. In the Type-B women, the high partum levels of Th1 cytokines and the absence of post-partum variation in ALT and HCV-RNA levels may be related to permanent Th1 cytokine stimulation.
Sponsorship: This work was supported by the Fondo de Investigaciones Sanitarias (FIS, Instituto de Salud Carlos III), [grant number PI080704]; Consejería de Salud (SAS), Junta de Andalucía, [grant number SAS111213] and Ciberehd (Ciber de Enfermedades Hepáticas y Digestivas (Instituto de Salud Carlos III).
Publisher: Public Library of Science (PLOS)
Keywords: Blood
Children
Cytokines
Evolutionary immunology
Liver disease and pregnancy
Mothers
Viral evolution
Viral load
URI: http://hdl.handle.net/10481/31038
ISSN: 1932-6203
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Ruiz-Extremera, A.; et al. Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C. Plos One, 8(10): e75613 (2013). [http://hdl.handle.net/10481/31038]
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