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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/30975

Title: Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction
Authors: Arrabal-Polo, Miguel Ángel
Arias-Santiago, Salvador
López Carmona-Pintado, Fernando
Merino-Salas, Sergio
Lahoz-García, Clara
Zuluaga-Gómez, Armando
Arrabal-Martín, Miguel
Issue Date: 2012
Abstract: Background. The end point of this study was to investigate the prevalence of MS in patients with ED in comparison with control subjects and to analyse the association with acute phase reactants (CRP, ESR) and hormone levels. Methods. This case-control study included 65 patients, 37 with erectile dysfunction, according to the International Index of Erectile Function (IIEF) from the Urology Department of San Cecilio University Hospital, Granada (Spain) and 28 healthy controls. The prevalence of metabolic syndrome was calculated according to ATP-III criteria. Hormone levels and acute phase parameters were studied in samples drawn. Results. The ATP-III criteria for MS were met by 64.9% of the patients with ED and only 9.5% of the controls (P < 0.0001, OR = 17.53, 95% CI: 3.52-87.37). Binary logistic regression analysis showed a strong association between patients with ED and MS, even after additional adjustment for confounding factors (OR = 20.05, 95% CI: 1.24-32.82, P < 0.034). Patients with hypogonadism presented a significantly higher prevalence of metabolic syndrome. Multiple linear regression analysis showed that systolic BP and CRP predicted 0.46 (model R-2) of IIEF changes. Conclusion. Chronic inflammation found in patients with ED might explain the association between ED and metabolic syndrome.
Publisher: Hindawi Publishing Corporation
Keywords: Endothelial dysfunction
Androgenetic alopecia
Aldosterone levels
Testosterone
Hypogonadism
Obesity
Men
Association
Deficiency
Disease
URI: http://hdl.handle.net/10481/30975
ISSN: 1537-744X
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Arrabal-Polo, M.A.; et al. Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction. Scientific World Journal, 2012: 272769 (2012). [http://hdl.handle.net/10481/30975]
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