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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/30965

Title: Deficits in Executive and Memory Processes in Delusional Disorder: A Case-Control Study
Authors: Ibañez-Casas, Inmaculada
Portugal, Enrique de
González, Nieves
McKenney, Kathryn Anne
Haro, Josep M.
Usall, Judith
Pérez García, Miguel
Cervilla Ballesteros, Jorge A.
Issue Date: 2013
Abstract: [Objective] Delusional disorder has been traditionally considered a psychotic syndrome that does not evolve to cognitive deterioration. However, to date, very little empirical research has been done to explore cognitive executive components and memory processes in Delusional Disorder patients. This study will investigate whether patients with delusional disorder are intact in both executive function components (such as flexibility, impulsivity and updating components) and memory processes (such as immediate, short term and long term recall, learning and recognition). [Methods] A large sample of patients with delusional disorder (n = 86) and a group of healthy controls (n = 343) were compared with regard to their performance in a broad battery of neuropsychological tests including Trail Making Test, Wisconsin Card Sorting Test, Colour-Word Stroop Test, and Complutense Verbal Learning Test (TAVEC). [Results] When compared to controls, cases of delusional disorder showed a significantly poorer performance in most cognitive tests. Thus, we demonstrate deficits in flexibility, impulsivity and updating components of executive functions as well as in memory processes. These findings held significant after taking into account sex, age, educational level and premorbid IQ. [Conclusions] Our results do not support the traditional notion of patients with delusional disorder being cognitively intact.
Sponsorship: This study was partially funded by grants from the Fondo de Investigaciones Sanitarias Instituto de Salud Carlos III, Ministry of economy and competitivity (Project No. FIS PI021813 and FIS PF09/01671), and by Proyecto de Excelencia, Consejeria de Innovacion, Junta de Andalucia (Project No. CTS 1686).
Publisher: Public Library of Science (PLOS)
Keywords: Attention
Cognition
Diagnostic medicine
Learning
Long-term memory
Memory
Schizophrenia
Working memory
URI: http://hdl.handle.net/10481/30965
ISSN: 1932-6203
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Ibañez-Casas, I.; et al. Deficits in Executive and Memory Processes in Delusional Disorder: A Case-Control Study. Plos One, 8(7): e67341 (2013). [http://hdl.handle.net/10481/30965]
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