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Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response
dc.contributor.author | González-Rey, Elena | |
dc.contributor.author | Martínez-Romero, Rubén | |
dc.contributor.author | O'Valle Ravassa, Francisco Javier | |
dc.contributor.author | Aguilar-Quesada, Rocío | |
dc.contributor.author | Conde, Carmen | |
dc.contributor.author | Delgado Mora, Mario | |
dc.contributor.author | Oliver Pozo, Francisco Javier | |
dc.date.accessioned | 2014-03-19T08:42:57Z | |
dc.date.available | 2014-03-19T08:42:57Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | González-Rey, E.; et al. Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response. Plos One, 2(10): e1071 (2007). [http://hdl.handle.net/10481/30951] | es_ES |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | doi: 10.1371/journal.pone.0001071 | |
dc.identifier.uri | http://hdl.handle.net/10481/30951 | |
dc.description.abstract | Poly(ADP-ribose) polymerase-1 (PARP-1) synthesizes and transfers ADP ribose polymers to target proteins, and regulates DNA repair and genomic integrity maintenance. PARP-1 also plays a crucial role in the progression of the inflammatory response, and its inhibition confers protection in several models of inflammatory disorders. Here, we investigate the impact of a selective PARP-1 inhibitor in experimental arthritis. PARP-1 inhibition with 5-aminoisoquinolinone (AIQ) significantly reduces incidence and severity of established collagen-induced arthritis, completely abrogating joint swelling and destruction of cartilage and bone. The therapeutic effect of AIQ is associated with a striking reduction of the two deleterious components of the disease, i.e. the Th1-driven autoimmune and inflammatory responses. AIQ downregulates the production of various inflammatory cytokines and chemokines, decreases the antigen-specific Th1-cell expansion, and induces the production of the anti-inflammatory cytokine IL-10. Our results provide evidence of the contribution of PARP-1 to the progression of arthritis and identify this protein as a potential therapeutic target for the treatment of rheumatoid arthritis. | es_ES |
dc.description.sponsorship | This work has been supported by grants CTS870 from Junta de Andalucia to MD, SAF 2003-01217, RNIHG c03/02, PI050972, SAF2006-01089 and FIS G03/152 to FJO. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science (PLOS) | es_ES |
dc.subject | Arthritis | es_ES |
dc.subject | Bone and joint mechanics | es_ES |
dc.subject | Cartilage | es_ES |
dc.subject | Cytokines | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Inflammatory diseases | es_ES |
dc.subject | Macrophages | es_ES |
dc.subject | Neutrophils | es_ES |
dc.title | Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |