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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/30945

Title: Brain Structural Correlates of Reward Sensitivity and Impulsivity in Adolescents with Normal and Excess Weight
Authors: Moreno-López, Laura
Soriano-Mas, Carles
Delgado-Rico, Elena
Schmidt Rio-Valle, Jacqueline
Verdejo-García, Antonio
Issue Date: 2012
Abstract: Introduction Neuroscience evidence suggests that adolescent obesity is linked to brain dysfunctions associated with enhanced reward and somatosensory processing and reduced impulse control during food processing. Comparatively less is known about the role of more stable brain structural measures and their link to personality traits and neuropsychological factors on the presentation of adolescent obesity. Here we aimed to investigate regional brain anatomy in adolescents with excess weight vs. lean controls. We also aimed to contrast the associations between brain structure and personality and cognitive measures in both groups.
Methods Fifty-two adolescents (16 with normal weight and 36 with excess weight) were scanned using magnetic resonance imaging and completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), the UPPS-P scale, and the Stroop task. Voxel-based morphometry (VBM) was used to assess possible between-group differences in regional gray matter (GM) and to measure the putative differences in the way reward and punishment sensitivity, impulsivity and inhibitory control relate to regional GM volumes, which were analyzed using both region of interest (ROI) and whole brain analyses. The ROIs included areas involved in reward/somatosensory processing (striatum, somatosensory cortices) and motivation/impulse control (hippocampus, prefrontal cortex).
Results Excess weight adolescents showed increased GM volume in the right hippocampus. Voxel-wise volumes of the second somatosensory cortex (SII) were correlated with reward sensitivity and positive urgency in lean controls, but this association was missed in excess weight adolescents. Moreover, Stroop performance correlated with dorsolateral prefrontal cortex volumes in controls but not in excess weight adolescents.
Conclusion Adolescents with excess weight have structural abnormalities in brain regions associated with somatosensory processing and motivation.
Sponsorship: This study has been funded by BRAINOBE from the Andalusia Council of Science and Innovation and INTEROBE (PSI2010-17290) from the Ministry of Economy and Competitiveness (PI: Antonio Verdejo-García). LML is supported by a FPU predoctoral research grant (AP2007-03583) from the Spanish Ministry of Science and Innovation. CSM is funded by a ‘Miguel Servet’ contract from the Carlos III Health Institute (CP10/00604).
Publisher: Public Library of Science (PLOS)
Keywords: Adolescents
Central nervous system
Magnetic resonance imaging
Motivation
Neuroimaging
Obesity
Personality
Prefrontal cortex
URI: http://hdl.handle.net/10481/30945
ISSN: 1932-6203
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Moreno-López, L.; et al. Brain Structural Correlates of Reward Sensitivity and Impulsivity in Adolescents with Normal and Excess Weight. Plos One, 7(11): e49185 (2012). [http://hdl.handle.net/10481/30945]
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