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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/29536

Title: Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation
Authors: Megía Fernández, Alicia
Hernández Mateo, Fernando
Santoyo González, Francisco
Issue Date: 2013
Abstract: The easy vinyl sulfone derivatization of ferrocene allows the preparation of some effective, versatile and valuable ferrocenylation reagents. The applicability of such compounds in conjugation and bioconjugation of amine and/or thiol containing molecules and biomolecules through Michael-type addition under mild conditions that preserve the biological function of the latter is described. The feasibility of the methodology is demonstrated by the preparation of a variety of conjugates and bioconjugates (ferrocenyl terminated dendrimers and ferrocene–sugar, ferrocene–cyclodextrin, ferrocene–peptide and ferrocene–protein conjugates).
Sponsorship: Financial support was provided by Ministerio de Ciencia e Innovación (CTQ2011-29299-CO2-01).
Publisher: Royal Society Chemistry
Keywords: Vinyl sulfone
Ferrocene
Synthesis
URI: http://hdl.handle.net/10481/29536
ISSN: 1477-0520
1477-0539
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Megía-Fernández, A.; Hernández-Mateo, F.; Santoyo-González, F. Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation. Organic and Biomolecular Chemistry 11(16): 2586-2596 (2013). [http://hdl.handle.net/10481/29536]
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