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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/29166

Title: Late pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case report
Authors: Cózar Olmo, José Manuel
Aptsiauri, Natalia
Tallada, Miguel
Garrido Torres-Puchol, Federico
Ruiz-Cabello, Francisco
Issue Date: 2008
Abstract: Introduction We report a case of pulmonary metastatic recurrence of renal adenocarcinoma soon after radical nephrectomy that was followed by renal transplant and immunosuppressive medication. Increased risk of metastatic recurrence of renal cell carcinoma should be considered in the immediate post-transplant period when immunosuppressive medication is administered, even if nephrectomy had been performed many years earlier.
Case presentation In 1986 the patient demonstrated renal insufficiency secondary to mesangial glomerulonephritis. In 1992 he underwent left side radical nephrectomy with histopathological diagnosis of clear cell adenocarcinoma. Mesangial glomerulonephritis in the remaining right kidney progressed to end-stage renal failure. In October 2000 he received a kidney transplant from a cadaver and commenced immunosuppressive medication. Two months later, several nodules were found in his lungs, which were identified as metastases from the primary renal tumor that had been removed with the diseased kidney 8 years earlier.
Conclusion Recurrence of renal cell carcinoma metastases points to tumor dormancy and reflects a misbalance between effective tumor immune surveillance and immune escape. This case demonstrates that a state of tumor dormancy can be interrupted soon after administration of immunosuppressant medication.
Sponsorship: This work was partially supported by the Fondo de Investigaciones Sanitarias (PI 02/0175), the plan Andaluz de Investigacion, and the Instituto de Salud Carlos III-Red de centros de Cancer, Spain.
Publisher: Biomed Central
Keywords: Metastases
Renal carcinoma
Transplantation
Amelogenin
Cell cycle
Inflammation
Angiogenesis
URI: http://hdl.handle.net/10481/29166
ISSN: 1752-1947
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Cózar, J.M; et al. Late pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case report. Journal of Medical Case Reports, 2: 111 (2008). [http://hdl.handle.net/10481/29166]
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