Universidad de Granada Digibug
 

Repositorio Institucional de la Universidad de Granada >
1.-Investigación >
Departamentos, Grupos de Investigación e Institutos >
Grupo: Evaluación Funcional y Fisiología del Ejercicio (CTS262) >
EFFE CTS-262 - Artículos >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/29017

Title: Physical activity attenuates the effect of low birth weight on insulin resistance in adolescents: findings from two observational studies
Authors: Ortega Porcel, Francisco B.
Ruiz, Jonatan R.
Hurtig-Wennlöf, A.
Meirhaeghe, Aline
González Gross, Marcela
Moreno, L. A.
Molnar, Dénes
Kafatos, A.
Gottrand, Frederic
Widhalm, Kurt
Labayen, Idoia
Sjöström, Michael
Issue Date: 2011
Abstract: OBJECTIVE: To examine whether physical activity influences the association between birth weight and insulin resistance in adolescents. RESEARCH DESIGN AND METHODS: The study comprised adolescents who participated in two cross-sectional studies: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study (n = 520, mean age = 14.6 years) and the Swedish part of the European Youth Heart Study (EYHS) (n = 269, mean age = 15.6 years). Participants had valid data on birth weight (parental recall), BMI, sexual maturation, maternal education, breastfeeding, physical activity (accelerometry, counts/minute), fasting glucose, and insulin. Insulin resistance was assessed by homeostasis model assessment-insulin resistance (HOMA-IR). Maternal education level and breastfeeding duration were reported by the mothers. RESULTS: There was a significant interaction of physical activity in the association between birth weight and HOMA-IR (logarithmically transformed) in both the HELENA study and the EYHS (P = 0.05 and P = 0.03, respectively), after adjusting for sex, age, sexual maturation, BMI, maternal education level, and breastfeeding duration. Stratified analyses by physical activity levels (below/above median) showed a borderline inverse association between birth weight and HOMA-IR in the low-active group (standardized β = -0.094, P = 0.09, and standardized β = -0.156, P = 0.06, for HELENA and EYHS, respectively), whereas no evidence of association was found in the high-active group (standardized β = -0.031, P = 0.62, and standardized β = 0.053, P = 0.55, for HELENA and EYHS, respectively). CONCLUSIONS: Higher levels of physical activity may attenuate the adverse effects of low birth weight on insulin sensitivity in adolescents. More observational data, from larger and more powerful studies, are required to test these findings.
Sponsorship: This work was mainly supported by the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034) and by grants from the Stockholm County Council. This study was also supported by grants from the Spanish Ministry of Education (EX-2008-0641, AP2006-02464), the Swedish Heart-Lung Foundation (20090635), the Swedish Council for Working Life and Social Research (Forskningsrådet för arbetsliv och socialvetenskap [FAS]), the Spanish Ministry of Health: Maternal, Child Health and Development Network (Number RD08/0072), and the Spanish Ministry of Science and Innovation (RYC-2010-05957).
Publisher: American Diabetes Association
Keywords: Adolescent
Cross-sectional studies
Excercise
Insulin resistance
URI: http://hdl.handle.net/10481/29017
ISSN: 0012-1797
1939-327X
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Ortega, F.B.; et al. Physical activity attenuates the effect of low birth weight on insulin resistance in adolescents: findings from two observational studies. Diabetes, 60(9): 2295-2299 (2011). [http://hdl.handle.net/10481/29017]
Appears in Collections:EFFE CTS-262 - Artículos

Files in This Item:

File Description SizeFormat
Ortega_InsulinResistance.pdf683.51 kBAdobe PDFView/Open
Recommend this item

This item is licensed under a Creative Commons License
Creative Commons

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! OpenAire compliant DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - Feedback

© Universidad de Granada