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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/28268

Title: Effect of mao-A and mao-B inhibitors in ganglia and nerve endings
Other Titles: Efecto de los inhibidores de mao-A y B en el ganglio y en los terminales nerviosos
Authors: Filinger, E.
Issue Date: 2000
Abstract: Se estudio el efecto de clorgilina y deprenil sobre la liberación y el metabolismo de 3H-noradrenalina (3H-NA) en el ganglio superior (GCS) y en la membrana nictitante (MN) de gato. Nuestros resultados muestran que en el GCS, clorgilina y deprenil redujeron del mismo modo la formación de 3,4-dihidroxi-fenilglicol (DOPEG) mientras que en la MN la disminución del DOPEG fue mayor con clorgilina que con deprenil. En el GCS la monoaminooxidasa (MAO) A y B cataliza la deaminación de NA a 3H-DOPEG, a 3H-3,4-acido-dihidroximandílico (3H-DOMA) o a los metabolitos 3H—O-metilados deaminados (3H-OMDA). En la MN la MAO-A presináptica cataliza la deaminación de NA principalmente a 3H-DOPEG, la MAO-B postsináptica a 3H-NMN y; la MAO-A y B a 3H-DOMA y 3H-OMDA.
The effect of clorgyline and deprenyl on the release and metabolism of 3H-noradrenaline (3H-NA) was studied in the superior cervical ganglion (SCG) and nictitating membrane (NM) of the cat. Our results show that in SCG, clorgyline and deprenyl reduced to the same degree the formation of 3,4-dihydroxy-phenylglycol (DOPEG) whereas in NM the decrease of DOPEG was more pronounced in presence of clorgyline than of deprenyl. In SCG the deamination of NA to either 3H-DOPEG, 3H-3,4-dihydroxymandelic acid (3H-DOMA) or 3H-0-methylated deaminated metabolites (3H-OMDA) is catalized by monoamineoxydase (MAO) A and B. In NM the deamination of NA to 3H-DOPEG is mainly catalized by MAO-A presynaptic, 3H-NMN by MAO-B postsynaptic, and 3H-DOMA and 3H-OMDA by MAO-A and B.
Publisher: Universidad de Granada, Facultad de Farmacia
Keywords: Clorgilina
Clorgyline
Deprenil
Deprenyl
MAO-A
MAO-B
URI: http://hdl.handle.net/10481/28268
ISSN: 0004-2927
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Filinger, E. Effect of mao-A and mao-B inhibitors in ganglia and nerve endings. Ars Pharm, 2000; 41(4): 357-363. [http://hdl.handle.net/10481/28268]
Appears in Collections:APh, vol. 41(4)

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