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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/28170

Title: Pérdida de la actividad antibacteriana de quinolonas por efecto de la radiación UVA
Other Titles: UVA-induced loss of quinolone antibacterial activity
Authors: Fernández, E.
Sánchez, G.
Navarrete, E.
Alcázar, F. del
Issue Date: 2004
Abstract: Se investiga la actividad antibacteriana de soluciones de las quinolonas ácido nalidíxico, ciprofloxacino y levofloxacino irradiadas mediante luz UVA. La fotólisis de las quinolonas produce una disminución de la actividad antibacteriana en cepas de E.coli y de S.aureus, evidenciándose un aumento de la concentración mínima inhibitoria de un 50% frente a las cepas ensayadas, en relación a las quinolonas no irradiadas. Se postula un mecanismo fotolítico radicalario con la consecuente fotodegradación de la porción γ-piridona-β-carboxílica responsable de la actividad antibacteriana.
The antibacterial activity of UVA-irradiated solutions of nalidixic acid, ciprofloxacin and levofloxacin was investigated. Photolysis of quinolones produced a decrease in antibacterial activity in strains of E. coli and S. aureus, becoming manifest through an increase of 50% in the minimum inhibitory concentration of the drug as compared to nonirradiated quinolones. In this study, it is suggested that a radical-mediated photolytic mechanism exists, leading to the photodegradation of the γ-piridone-β-carboxylic group, which is the mediator that is responsible for the drugs antibacterial activity.
Publisher: Universidad de Granada, Facultad de Farmacia
Keywords: Quinolonas
Quinolones
Fotolisis
Photolysis
CMI
MIC
Fotodegradación
Photodegradation
URI: http://hdl.handle.net/10481/28170
ISSN: 0004-2927
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Fernández, E.; et al. Pérdida de la actividad antibacteriana de quinolonas por efecto de la radiación UVA. Ars Pharm, 2004; 45 (2): 111-119. [http://hdl.handle.net/10481/28170]
Appears in Collections:APh, vol. 45(2)

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