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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/27777

Title: Could radiotherapy effectiveness be enhanced by electromagnetic field treatment?
Authors: Artacho-Cordón, Francisco
Salinas-Asensio, María del Mar
Calvente, Irene
Ríos-Arrabal, Sandra
León, Josefa
Román-Marinetto, Elisa
Olea, Nicolás
Núñez, María Isabel
Issue Date: Jul-2013
Abstract: One of the main goals in radiobiology research is to enhance radiotherapy effectiveness without provoking any increase in toxicity. In this context, it has been proposed that electromagnetic fields (EMFs), known to be modulators of proliferation rate, enhancers of apoptosis and inductors of genotoxicity, might control tumor recruitment and, thus, provide therapeutic benefits. Scientific evidence shows that the effects of ionizing radiation on cellular compartments and functions are strengthened by EMF. Although little is known about the potential role of EMFs in radiotherapy (RT), the radiosensitizing effect of EMFs described in the literature could support their use to improve radiation effectiveness. Thus, we hypothesized that EMF exposure might enhance the ionizing radiation effect on tumor cells, improving the effects of RT. The aim of this paper is to review reports of the effects of EMFs in biological systems and their potential therapeutic benefits in radiotherapy.
Sponsorship: This study was supported by the Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (PI08/0728, Fondos FEDER) to M.I. Núñez. F. Artacho-Cordón is supported by the Spanish Ministry of Science and Education (AP2012-2524). A grant from the Fundación Benéfica San Francisco Javier y Santa Cándida, University of Granada, to S. Ríos-Arrabal greatly aided this work. This research was also funded by the San Cecilio University Hospital, Granada.
Publisher: MDPI
Keywords: Electromagnetic fields
Cancer
ELF magnetic exposure
Radiotherapy
Genotoxicity
URI: http://hdl.handle.net/10481/27777
ISSN: 1422-0067
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Artacho-Cordón, F.; et al. Could radiotherapy effectiveness be enhanced by electromagnetic field treatment?. International Jorunal of Molecular Sciences, 14(7): 14974-14995 (2013). [http://hdl.handle.net/10481/27777]
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