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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/27473

Title: Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material
Authors: Lakshmana Prabu, S.
Shirwaikar, A.A.
Shirwaikar, A.
Ravikumar, G.
Kumar, A.
Jacob, A.
Issue Date: 2009
Abstract: Rosin, a natural resin, was used as a hydrophobic matrix material for the controlled release, using diltiazem HCl as model drug. Matrix tablets were prepared by direct compression method using rosin as matrix forming material in different proportions and with different diluent combinations. The tablets prepared were flat faced, retained their shape throughout. The method of preparation of matrix system and its concentration were found to have pronounced effect on the release of diltiazem HCl. The release was found to follow both the first order kinetics and fickian diffusion. The drug delivery was analyzed using the paddle method according to USP XXIII. All the studies were done in phosphate buffer pH 7.4. The matrix tablets were evaluated for its thickness, hardness, friability, weight variation, drug content and invitro release studies. The results suggest that the rosin is useful in developing sustained release matrix tablets, prolong release of water soluble drug for up to 24h. Rosin thus promises considerable utility in the development of oral sustained release drug delivery systems.
Publisher: Universidad de Granada, Facultad de Farmacia
Keywords: Compatibility
Differential scanning calorimetry
Diltiazem Hydrochloride
Sustained release matrix
Tablet excipients
URI: http://hdl.handle.net/10481/27473
ISSN: 0004-2927
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Lakshmana Prabu, S.; et al. Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material. Ars Pharm, 2009; 50(1): 32-42. [http://hdl.handle.net/10481/27473]
Appears in Collections:APh, vol. 50(1)

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