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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/27466

Title: Drug delivery systems based on poly(e-caprolactone) for cancer treatment
Other Titles: Sistemas transportadores de fármacos basados en el polímero poly(e- caprolactona) para el tratamiento del cáncer
Authors: Sáez-Fernández, E.
Ruiz Martínez, María A.
Arias Mediano, José Luis
Issue Date: 2009
Abstract: Chemotherapy agents have little or no specificity over cancer cells, resulting in low therapeutic concentrations at the tumor site (a consequence of a broad systemic distribution), and severe side effects. With the aim of avoiding cancer therapy failure, several approaches such as design of new anticancer drugs, chemical engineering of conventional drugs and development of drug delivery systems have been proposed. The objective is to enhance drug localization at the tumor region (by controlling its biodistribution profile) and, therefore, to increase the anti-tumor efficacy (even in multi-drug resistant tumors), while reducing systemic side effects. One of the most promising approaches to the problem is the development of drug nanocarriers based on the polymer poly(e-caprolactone). In this review we will focus our attention on these polymeric colloids, particularly on the most significant characteristics and formulation procedures, and on their use as nanoplatforms for the delivery of chemotherapy agents to the tumor site. Furthermore, the most recent in vitro and in vivo investigations on the subject are extensively reviewed.
Publisher: Universidad de Granada, Facultad de Farmacia
Keywords: Anti-tumor drug
Controlled release
Drug carriers
Drug delivery
Polymeric particles
URI: http://hdl.handle.net/10481/27466
ISSN: 0004-2927
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Sáez-Fernández, E.; Ruiz Martínez, M.A.; Arias Mediano, J.L. Drug delivery systems based on poly(e-caprolactone) for cancer treatment. Ars Pharm, 2009; 50(2): 83-96. [http://hdl.handle.net/10481/27466]
Appears in Collections:APh, vol. 50(2)

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