Development of a single combined microencapsulated formulation of allopurinol and nimesulide and investigation of their release behaviours
Metadatos
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Universidad de Granada, Facultad de Farmacia
Materia
Ibuprofen Sustained release Hydrophilic matrix HPMC Direct compression
Fecha
2010Referencia bibliográfica
Khan, S.A.; et al. Development of a single combined microencapsulated formulation of allopurinol and nimesulide and investigation of their release behaviours. Ars Pharm 2010; 51(2): 105-116. [http://hdl.handle.net/10481/27416]
Resumen
The aim of this study was to develop a single combined once-daily sustained release
microencapsulated dosage form of Allopurinol and Nimesulide using Ethyl cellulose as release
controlling factor and to evaluate drug release parameters as per various release kinetic models. In
order to achieve required sustained release profile, microparticles were prepared using coacervation
thermal change technique. The formulated microparticles were also characterized by physical and
chemical parameters and results were found in acceptable limits. Different dissolution models were
applied to drug release data in order to evaluate release mechanisms and kinetics. The drug release data fit well to the Higuchi expression. Drug release mechanism was found as a complex anomalous one.