Universidad de Granada Digibug
 

Repositorio Institucional de la Universidad de Granada >
2.-Revistas >
ARS Pharmaceutica >
Ars Pharma 2010, Vol. 51 >
APh, vol. 51(2) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/27416

Title: Development of a single combined microencapsulated formulation of allopurinol and nimesulide and investigation of their release behaviours
Authors: Khan, S.A.
Ahmad, M.
Murtaza, G.
Aamir, M.N.
Madni, A.
Kousar, R.
Minhas, U.
Issue Date: 2010
Abstract: The aim of this study was to develop a single combined once-daily sustained release microencapsulated dosage form of Allopurinol and Nimesulide using Ethyl cellulose as release controlling factor and to evaluate drug release parameters as per various release kinetic models. In order to achieve required sustained release profile, microparticles were prepared using coacervation thermal change technique. The formulated microparticles were also characterized by physical and chemical parameters and results were found in acceptable limits. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. The drug release data fit well to the Higuchi expression. Drug release mechanism was found as a complex anomalous one.
Publisher: Universidad de Granada, Facultad de Farmacia
Keywords: Ibuprofen
Sustained release
Hydrophilic matrix
HPMC
Direct compression
URI: http://hdl.handle.net/10481/27416
ISSN: 0004-2927
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Khan, S.A.; et al. Development of a single combined microencapsulated formulation of allopurinol and nimesulide and investigation of their release behaviours. Ars Pharm 2010; 51(2): 105-116. [http://hdl.handle.net/10481/27416]
Appears in Collections:APh, vol. 51(2)

Files in This Item:

File Description SizeFormat
Ars Pharm 2010;51(2)105-116.pdf279.1 kBAdobe PDFView/Open
Recommend this item

This item is licensed under a Creative Commons License
Creative Commons

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! OpenAire compliant DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - Feedback

© Universidad de Granada