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Ars Pharma 2009, Vol. 50 >
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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/27390

Title: Design and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers.
Authors: Rajan, R.
Sheba Rani, N.D.
Kajal, G.
Sanjoy Kumar, D.
Jasmina, K.
Arunabha, N.
Issue Date: 2010
Abstract: The release and permeation studies were carried out for developing transdermal therapeutic systems with chlorpheniramine maleate (CPM). The patches were prepared with eudragit RS-100 and RL-100 with/without polyvinyl pyrrolidone (PVP) and dibutyl phthalate (DBP) in different compositions. Thickness, tensile strength, drug content, moisture content and water absorption studies of the patches were measured. In vitro release/permeation of CPM was studied in modified Keshary-Chien diffusion cell. Chemical enhancers like l-menthol, oleic acid and phospholipon80 were added to compare the release pattern of the drug. The percent release of the drug from matrix patch increased with increase of PVP & DBP but the tensile strength decreased with the increase of DBP & PVP. Experimental release/permeation data of different formulations of the matrix systems are reported. Also the drug-polymer interaction was investigated by ATR-FTIR studies. The discussion was correlated the efficient matrix dispersion patch from suitable eudragit polymers for transdermal antihistamine applications in film device industry.
Publisher: Universidad de Granada, Facultad de Farmacia
Keywords: Matrix patch
Chlorpheniramine malaeate
Chemical enhancers
Dibutyl phthalate
Eudragit polymer
Polyvinyl pyrrolidone
URI: http://hdl.handle.net/10481/27390
ISSN: 0004-2927
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Rajan, R.;[et. al]. Design and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers. Ars Pharm, 2010, Vol.50 nº 4; 177-194.[http://hdl.handle.net/10481/27390]
Appears in Collections:APh, vol. 50(4)

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