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dc.contributor.authorRaja Sekharan, T.
dc.contributor.authorPalanichamy, S.
dc.contributor.authorShanmuganathan, S.
dc.contributor.authorTamilvanan, S.
dc.contributor.authorThanga Thirupath, A.
dc.date.accessioned2013-07-02T09:58:44Z
dc.date.available2013-07-02T09:58:44Z
dc.date.issued2009
dc.identifier.citationRaja Sekharan, T.; [et. al]. Formulation and evaluation of Theophylline controlled release matrix tablets using Guar gum. Ars Pharm, 2009, Vol.50 nº 4; 205-214.[http://hdl.handle.net/10481/27389]es_ES
dc.identifier.issn0004-2927
dc.identifier.urihttp://hdl.handle.net/10481/27389
dc.description.abstractTheophylline controlled release matrix tablets were prepared with guar gum in two ratios and with three different hardness of 5, 6 and 7kg/cm2. Theophylline controlled release granules were prepared and evaluated for the angle of repose, bulk density, tapped density, compressibility index and hausners ratio. All the formulation showed good flow properties. The compressed tablets were evaluated for the hardness, uniformity of weight, friability, drug content and invitro dissolution studies. All the formulations showed compliance with pharmacopial standards. There was no interaction between drug, polymer and other excipients. It was confirmed by FTIR studies. Among all the formulations F6 (i.e. polymer ratio1:2 and hardness 7kg/cm2) showed prolong release when compare to other formulations. The drug release kinetics showed zero order. The optimum formulation (F6) was stable when it was stored at 40 + 20 C, 280 + 20 C and at 450 + 20 C for 6 months.es_ES
dc.language.isoenges_ES
dc.publisherUniversidad de Granada, Facultad de Farmaciaes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectControlled releasees_ES
dc.subjectGuar gumes_ES
dc.subjectMatrix tabletses_ES
dc.subjectTheophyllinees_ES
dc.titleFormulation and evaluation of Theophylline controlled release matrix tablets using Guar gum.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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