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Ars Pharma 2010, Vol. 51 >
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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/27358

Title: Comparative Investigation on in vitro release of extemporaneously prepared norfloxacin semisolid formulations with marketed silver sulfadiazine 1% cream, USP using model independent approach
Authors: Dua, Kamal
Pabreja, Kavita
Ramana, M.V.
Issue Date: 2010
Abstract: Objective In an attempt for better treatment of bacterial infections, various semisolid formulations containing 5% w/w of norfloxacin were prepared and evaluated for in vitro drug release and in vitro skin permeability using dialysis membrane and rat abdominal skin respectively. The in vitro diffusion and permeation profile of the prepared formulation was compared with marketed silver sulfadiazine cream 1%, USP using model independent approach. Methods Various semisolid formulations were prepared with different dermatological bases using standard procedures. In vitro diffusion and permeation studies were carried out using Keshary-Chein (KC) type diffusion cell using dialysis membrane and rat abdominal skin respectively. Results The f1 lower than 15 and f2 higher than 50 indicated similarities in the in vitro diffusion and permeation profiles of the extemporaneously prepared selected semisolid formulations and marketed silver sulfadiazine 1% cream, USP. Conclusion Amongst all the semisolid formulations prepared, carbopol gel base was found to be most suitable dermatological base for norfloxacin, the results obtained for in vitro diffusion, and in vitro skin permeation studies are comparable with that of marketed silver sulphadiazine 1% cream, USP.
Publisher: Universidad de Granada, Facultad de Farmacia
Keywords: Semisolid
Ointments
Norfloxacin
URI: http://hdl.handle.net/10481/27358
ISSN: 0004-2927
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Dua, K.; Pabreja, K.; Ramana, M.V. Comparative Investigation on in vitro release of extemporaneously prepared norfloxacin semisolid formulations with marketed silver sulfadiazine 1% cream, USP using model independent approach. Ars Pharm 2010; 51 (4):177-185. [http://hdl.handle.net/10481/27358]
Appears in Collections:APh, vol. 51(4)

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