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dc.contributor.authorGhaisas, Mahesh M.
dc.contributor.authorNavghare, V.V.
dc.contributor.authorTakawale, A.R.
dc.contributor.authorZope, V.S.
dc.contributor.authorPhanse, M.A.
dc.date.accessioned2013-07-01T07:11:19Z
dc.date.available2013-07-01T07:11:19Z
dc.date.issued2010
dc.identifier.citationGhaisas, M.M.; et al. Antidiabetic and nephroprotective effect of tectona grandis linn. In alloxan induced diabetes. Ars Pharm 2010; 51 (4):195-206. [http://hdl.handle.net/10481/27352]es_ES
dc.identifier.issn0004-2927
dc.identifier.urihttp://hdl.handle.net/10481/27352
dc.description.abstractIn the present study, effect of ethanolic extract of bark of Tectona grandis Linn. (TG) was evaluated using alloxan induced diabetes and associated renal complication. The diabetes was induced by administration of alloxan to the rats at the dose of 140 mg/kg, i.p. TG was administered to diabetic animals for six weeks and various biochemical parameters in blood and urine (plasma glucose, serum albumin, total protein, and creatinine, urine total protein, urine albumin), tissue parameters (cholesterol and triglyceride in kidney homogenate) and % change in body weight were evaluated along with histopathological study. In present study diabetic animals treated with TG showed significant reduction in the elevated level of plasma glucose (p<0.01) when compared with diabetic control. While considering renal parameters, diabetic animals treated with TG showed significant decrease in serum creatinine (p<0.05), urine albumin and urine total protein levels (p<0.01) and significant increase in serum albumin, total protein and % change in body weight (p<0.01) when compared with diabetic control. Diabetic control showed significant increase in total cholesterol and triglyceride accumulation in kidney, while diabetic animals treated with TG showed significant decrease in levels of total cholesterol (p<0.01) and triglyceride (p<0.05) in the kidney when compared with diabetic control. Diabetic control showed significant mark of glomerulosclerosis and hyalinization which occurs because of severe diabetic condition (diabetic nephropathy). Diabetic groups treated with TG showed absence of the sclerotic lesions produced by diabetic condition. Hence, the results obtained in the present study indicate that Tectona grandis has the potential to treat diabetes mellitus and prevent the associated renal damage.es_ES
dc.language.isoenges_ES
dc.publisherUniversidad de Granada, Facultad de Farmaciaes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectAlloxanes_ES
dc.subjectCreatininees_ES
dc.subjectGlucosees_ES
dc.subjectNephropathyes_ES
dc.subjectTectona grandises_ES
dc.titleAntidiabetic and nephroprotective effect of tectona grandis linn. In alloxan induced diabeteses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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