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Formulation and evaluation of controlled release matrix tablet of diltiazem HCl by using HPMC and guar gum as polymeric matrix material
dc.contributor.author | Shah, UH. | |
dc.contributor.author | Patel, B.K. | |
dc.contributor.author | Patel, M.R. | |
dc.date.accessioned | 2013-06-11T06:30:42Z | |
dc.date.available | 2013-06-11T06:30:42Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Shah, U.H.; Patel, B.K.; Patel, M.R. Formulation and evaluation of controlled release matrix tablet of diltiazem HCl by using HPMC and guar gum as polymeric matrix material. Ars Pharm. 2012; 53(4): 16-20. [http://hdl.handle.net/10481/26297] | es_ES |
dc.identifier.issn | 0004-2927 | |
dc.identifier.uri | http://hdl.handle.net/10481/26297 | |
dc.description.abstract | Aim: The present investigation concerns the development of controlled release matrix tablet of Diltiazem HCl. Methods: Matrix tablet of Diltiazem HCl was formulated by using HPMC and Guar gum as a polymeric matrix forming materials in various concentrations (%w/w) to study their ability to retard the release. The tablets were prepared by wet granulation method and evaluated for physical properties, content uniformity, swelling index, stability and in-vitro drug release. Results: Swelling was increased as the concentration and viscosity of HPMC increases. Tablets formulated using guar gum and HPMC alone were gave initial burst effect followed by controlled release for 8 hr. It was evident from the study that the formulationsF7,F8 &F9 have optimum swelling index and in vitro drug release up to 44% in 8hrs. The stability studies of optimized batch showed that there was no change in hardness, swelling index and in-vitro release up to 12 weeks. Conclusions: The batches F7, F8 and F9 possessed the high potential to release the drug gradually for more than 8 hours. The zero-order release kinetic indicates concentration independent drug release ensuring that the formulated tablet showed promising result to be a sustained release formulation. | es_ES |
dc.description.abstract | Objetivos: En el presente trabajo se describe el desarrollo de comprimidos matriciales de clorhidrato de diltiazem. Métodos: Se obtienen comprimidos matriciales mediante el uso de goma guar y HPMC. Se estudian distintas formulaciones en las que se cambia la composición de estos materiales matriciales como controladores de la cesión. Los comprimidos se prepararon por el método de granulación húmeda y se evaluaron uniformidad de contenido, índice de hinchamiento, estabilidad y velocidad de liberación. Resultados: La capacidad de hinchamiento aumenta con el porcentaje utilizado de HPMC. Las formulaciones F7, F8 y F9 son las que muestran mejores características de liberación. Los estudios de estabilidad de la formulación seleccionada demuestran una buena resistencia a la rotura, capacidad de hinchamiento y control de la velocidad de disolución durante el estudio de estabilidad. Conclusiones: Las formulaciones F7, F8 y F9 tienen unas buenas propiedades de control de liberación del fármaco durante al menos 8 horas. La cinética de liberación se pueden ajustar a un orden cero. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Universidad de Granada, Facultad de Farmacia | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | es_ES |
dc.subject | HPMC | es_ES |
dc.subject | Guar gum | es_ES |
dc.subject | Goma guar | es_ES |
dc.subject | Diltiazem HCl | es_ES |
dc.subject | Diltiazem HCl | es_ES |
dc.subject | Controlled release | es_ES |
dc.subject | Liberación controlada | es_ES |
dc.subject | Matrix tablets | es_ES |
dc.subject | Comprimidos matriciales | es_ES |
dc.title | Formulation and evaluation of controlled release matrix tablet of diltiazem HCl by using HPMC and guar gum as polymeric matrix material | es_ES |
dc.title.alternative | Formulación y evaluación de liberación controlada matriz del comprimido de Diltiazem HCl utilizando goma de guar HPMC y como material de matriz polimérica | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |