Universidad de Granada Digibug
 

Repositorio Institucional de la Universidad de Granada >
2.-Revistas >
ARS Pharmaceutica >
Ars Pharma 2011, Vol. 52 >
APh, vol. 52(3) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/26237

Title: Rapidly disintegrating tablets of metoclopramide hydrochloride using novel chemically modified cellulose
Authors: Aloorkar, N.H.
Bhatia, M.S.
Issue Date: 2011
Abstract: The purpose of the study was to modify cellulose using hydrochloride salt of 2-aminoethanoyl chloride with optimum hydrophilic and hydrophobic properties to impart it a superdisintegrant activity and also to formulate and evaluate rapidly disintegrating tablets of metoclopramide hydrochloride using this novel chemically modified cellulose. A novel polymer, chemically modified cellulose was synthesized by chemically modifying microcrystalline cellulose with hydrochloride salt of 2-aminoethanoyl chloride. The formation of novel polymer was confirmed by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy and by differential scanning calorimetric (DSC) and elemental analysis. The toxicity study proved the novel modified cellulose to be non toxic. Rapidly disintegrating tablets of metoclopramide hydrochloride were prepared using novel modified cellulose and compared for the release of drug with control formulation, prepared using non modified microcrystalline cellulose. The tests like wetting time, water absorption ratio and in vitro disintegration time were carried out to elucidate the relationship between them. The study revealed that novel modified cellulose in a concentration of 2% released the drug faster than at a concentration higher than that. Hence it could be concluded that microcrystalline cellulose, a polymer which is devoid of superdisintegrant activity, can suitably be modified by controlled chemical modification of it with hydrochloride salt of 2-aminoethanoyl chloride or similar groups with optimum hydrophilicity and hydrophobicity to convert it into a superdisintegrant material. It can also be concluded that rapidly disintegrating tablets of metoclopramide hydrochloride can suitably be developed for the efficient management of emesis
Publisher: Universidad de Granada, Facultad de Farmacia
Keywords: Chemically modified cellulose
Microcrystalline cellulose
Metoclopramide hydrochloride
Rapidly disintegrating tablets
Superdisintegrant
URI: http://hdl.handle.net/10481/26237
ISSN: 0004-2927
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Aloorkar, N.H.; Bhatia, M.S. Rapidly disintegrating tablets of metoclopramide hydrochloride using novel chemically modified cellulose. Ars Pharm. 2011; 52(3): 26-34. [http://hdl.handle.net/10481/26237]
Appears in Collections:APh, vol. 52(3)

Files in This Item:

File Description SizeFormat
ARS Pharm 2011;52(3)26-34-pdf-625.pdf683.62 kBAdobe PDFView/Open
Recommend this item

This item is licensed under a Creative Commons License
Creative Commons

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! OpenAire compliant DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - Feedback

© Universidad de Granada