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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/24961

Title: Determination of bisphenol A and related aromatic compounds released from bis-GMA-based composites and sealants by high performance liquid chromatography
Authors: Pulgar Encinas, Rosa María
Olea Serrano, Fátima
Novillo-Fertrell, Arancha
Rivas, A.
Pazos, Patricia
Pedraza Muriel, Vicente
Navajas, José M.
Olea, Nicolás
Issue Date: 2000
Abstract: Most of the composites and sealants used in dentistry are based on bisphenol A diglycidylether methacrylate (Bis-GMA). Reports revealed that in situ polymerization is not complete and that free monomers can be detected by different analytic methods. Concerns about the estrogenicity of bisphenol A (BPA) and other aromatic components leached from commercial products have been expressed. We studied biphenolic components eluted from seven composites and one sealant before and after in vitro polymerization using HPLC and gas chromatography/mass spectrometry and we investigated how pH modifications affect the leaching of these components. We found BPA (maximal amount 1.8 microg/mg dental material), its dimethacrylate derivative (Bis-DMA, 1.15 microg/mg), bisphenol A diglycidylether (6. 1 microg/mg), Bis-GMA (2.0 microg/mg), and ethoxylate and propoxylate of bisphenol A in media in which samples of different commercial products were maintained under controlled pH and temperature conditions. Our results confirm the leaching of estrogenic monomers into the environment by Bis-GMA-based composites and sealants in concentrations at which biologic effects have been demonstrated in in vivo experimental models. The main issue with implications for patient care and dentist responsibility is to further determine the clinical relevance of this estrogenic exposure.
Sponsorship: This research was supported by grants from the Spanish Ministry of Health (FIS, 95/1959) and Education (CICYT, AMB97-1194-CE) and the Andalusian Regional Government, Department of Health (Consejeria de Salud, JA, 231/97).
Publisher: National Institute of Environmental Health Sciences
Description: 'Reproduced with permission from Environmental Health Perspectives'
Keywords: Bis-GMA
Bisphenol A
Bisphenol A dimethacrylate
Dental composites and sealants
URI: http://hdl.handle.net/10481/24961
ISSN: 0091-6765
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Pulgar, R.; et al. Determination of bisphenol A and related aromatic compounds released from bis-GMA-based composites and sealants by high performance liquid chromatography. Environmental Health Perspectives, 108(1): 21-27 (2000). [http://hdl.handle.net/10481/24961]
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