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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/24820

Title: Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
Authors: Saal, Frederick S. vom
Akingbemi, Benson T.
Belcher, Scott
Birnbaun, Linda S.
Crain, D. Andrew
Eriksen, Marcus
Farabollini, Francesca
Guillette, Louis J.
Hauser, Russ
Heindel, Jerrold J.
Ho, Shuk-Mei
Hunt, Patricia A.
Iguchi, Taisen
Jobling, Susan
Kanno, Jun
Keri, Ruth A.
Knudsen, Karen E.
Laufer, Hans
LeBlanc, Gerald A.
Marcus, Michele
McLachlan, John A.
Myers, John Peterson
Nadal, Ángel
Newbold, Retha R.
Olea, Nicolás
Prins, Gail S.
Richter, Catherine A.
Rubin, Beverly S.
Sonnenschein, Carlos
Soto, Ana M.
Talsness, Chris E.
Vandenbergh, John G.
Vandenberg, Laura N.
Walser-Kuntz, Debby R.
Watson, Cheryl S.
Welshons, Wade V.
Wehterill, Yelena
Zoeller, Thomas R.
Issue Date: 2007
Abstract: This document is a summary statement of the outcome from the meeting: “Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health” sponsored by both the NIEHS and NIDCR at NIH/DHHS, as well as the US-EPA and Commonweal on the estrogenic environmental chemical bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl)propane; CAS# 80-05-7). The meeting was held in Chapel Hill, NC, 28–30 November 2006 due to concerns about the potential for a relationship between BPA and negative trends in human health that have occurred in recent decades. Examples include increases in abnormal penile/urethra development in males, early sexual maturation in females, an increase in neurobehavioral problems such as attention deficit hyperactivity disorder (ADHD) and autism, an increase in childhood and adult obesity and type 2 diabetes, a regional decrease in sperm count, and an increase in hormonally mediated cancers, such as prostate and breast cancers. Concern has been elevated by published studies reporting a relationship between treatment with “low doses” of BPA and many of theses negative health outcomes in experimental studies in laboratory animals as well as in vitro studies identifying plausible molecular mechanisms that could mediate such effects. Importantly, much evidence suggests that these adverse effects are occurring in animals within the range of exposure to BPA of the typical human living in a developed country, where virtually everyone has measurable blood, tissue and urine levels of BPA that exceed the levels produced by doses used in the “low dose” animal experiments.
Publisher: Elsevier
Keywords: Bisphenol A
In vitro
In vivo
Rat
Mouse
Aquatic animal
Cancer
Low dose
Non-monotonic dose-response curves
Developmental programming
URI: http://hdl.handle.net/10481/24820
ISSN: 0890-6238
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Saal, F.S.; et al. Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reproductive Toxicology, 24(2): 131-138 (2007). [http://hdl.handle.net/10481/24820]
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