Grupo: Periodoncia e Implantes (CTS583)
https://hdl.handle.net/10481/53872
2024-03-28T09:22:16ZAltilix® Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study
https://hdl.handle.net/10481/58543
Altilix® Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study
Castellino, Giuseppa; Magán Fernández, Antonio
The objective was to evaluate the effects of 6 months of supplementation with Altilix®,
containing chlorogenic acid and its derivatives, and luteolin and its derivatives, on cardiovascular
risk and hepatic markers in subjects with metabolic syndrome (MetS). A randomized, double-blind,
placebo-controlled study was performed in 100 subjects with MetS with a follow-up period of
6 months; 50 subjects were randomized to Altilix® (26 men and 24 women, mean age 63 8 years)
and the other 50 to placebo (28 men and 22 women, mean age 63 11 years). Anthropometric,
cardiometabolic, and hepatic parameters were assessed at baseline and at the end of follow-up.
Carotid intima-media thickness and endothelial function were assessed by doppler ultrasound and by
flow-mediated dilation of the brachial artery, respectively. The presence and degree of non-alcoholic
fatty liver disease (NAFLD) was assessed by the fatty liver index (FLI), and subjects were divided
into three subgroups: (1) without NAFLD; (2) with borderline NAFLD; and (3) with NAFLD. After
6 months of Altilix® supplementation, we found a significant improvement vs. placebo in most of
the evaluated parameters, including body weight (-2.40% (95% CI -3.79, -1.01); p < 0.001), waist
circumference (-2.76% (95% CI -4.55, -0.96); p = 0.003), HbA1c (-0.95% (95% CI -1.22, -0.67);
p < 0.001), plasma lipids, FLI (-21.83% (95% CI -27.39, -16.27); p < 0.001), hepatic transaminases,
flow-mediated dilation (10.56% (95% CI 5.00, 16.12); p < 0.001), and carotid intima-media thickness
(-39.48% (95% CI -47.98, -30.97); p < 0.001).
Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers
https://hdl.handle.net/10481/57855
Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers
Pozo, Elena; Mesa Aguado, Francisco Luis; Ikram, Mohamed H.; Puertas Prieto, Alberto; Torrecillas-Martínez, Laura; Ortega-Oller, Inmaculada; Magán Fernández, Antonio; Rodríguez-Martínez, María Dolores; Padial Molina, Miguel; Sánchez Fernández, Elena; Galindo Moreno, Pablo Antonio; O'Valle Ravassa, Francisco Javier
The objective of this study was to determine
whether gynecological and periodontal clinical
parameters and the immunohistochemical expression in
placental chorionic villi of the markers cyclooxygenase-
2 (COX-2), interleukin (IL)-1β, vascular endothelial
growth factor receptor 1 (VEGFR1), podoplanin, and
Heat Shock Protein (HSP70) are associated with preterm
birth (PB) and/or low birth weight (LBW) neonates.
Material and methods: An observational casecontrol
study was performed in 130 puerperal women:
mothers of PB/LBW neonates (cases, n=65) and mothers
of full-term normal-weight neonates (controls, n=65).
Data were gathered from all participants on sociodemographic,
gynecological, and periodontal variables
and on placental immunohistochemical COX-2, IL-1β,
VEGFR1, podoplanin, and HSP70 expression.
Results: Among the 42 women with mild/moderate
periodontitis or gingivitis, the studied periodontal
variables were significantly worse and the placental
COX-2 (p=0.043), HSP70 (p=0.001), IL-1β (p=0.001),
VEGFR1 (p=0.032), and podoplanin (p=0.058)
expressions were significantly higher in the cases than in
the controls. In comparison to the mothers without
periodontitis, only COX-2 (p=0.026) and VEGFR1 (p=0.005) expressions were significantly increased in
those with the disease. Increased COX-2 values were
detected in the women with a history of genitourinary
infection (p=0.036), premature rupture of membrane
(p=0.012), or drug treatment (p=0.050).
Conclusions: The etiology of preterm birth and/or
low birth weight is multifactorial and involves
consumption habits, social-health factors, and infectious
episodes. These adverse pregnancy outcomes were
associated with periodontitis and the increased placental
expression of IL-1β, COX-2, VEGFR1, and HSP70.