Departamento de Química Farmacéutica y Orgánica
https://hdl.handle.net/10481/31132
2024-03-29T02:25:51ZSynthesis of 1,4-benzoxathiin-9H-purine derivatives as antiproliferative agents
https://hdl.handle.net/10481/87959
Synthesis of 1,4-benzoxathiin-9H-purine derivatives as antiproliferative agents
Cruz López, Olga María; Campos Rosa, Joaquín María; Conejo García, Ana
Benzo‐Fused Seven‐ and Six‐Membered Derivatives Linked to Pyrimidines or Purines Induce Apoptosis of Human Metastatic Breast Cancer MCF‐7 Cells in Vitro
https://hdl.handle.net/10481/87958
Benzo‐Fused Seven‐ and Six‐Membered Derivatives Linked to Pyrimidines or Purines Induce Apoptosis of Human Metastatic Breast Cancer MCF‐7 Cells in Vitro
Campos Rosa, Joaquín María; Conejo García, Ana; Cruz López, Olga María; Núñez Carretero, María Del Carmen
Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4’-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene
https://hdl.handle.net/10481/87954
Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4’-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene
Romagnoli, Romeo; Cruz López, Olga María; López Cara, Luisa Carlota
Bozepinib: A Promising Selective Derivative Targeting Breast Cancer Stem Cells
https://hdl.handle.net/10481/87953
Bozepinib: A Promising Selective Derivative Targeting Breast Cancer Stem Cells
Campos Rosa, Joaquín María; Conejo García, Ana; Cruz López, Olga María
Relationship between HMF intake and SMF formation in vivo: An animal and human study
https://hdl.handle.net/10481/87951
Relationship between HMF intake and SMF formation in vivo: An animal and human study
Pastoriza de la Cueva, Silvia; Montilla Gómez, Javier; Cruz López, Olga María; Delgado-Andrade, Cristina; Rufián Henares, José Ángel
Scope
5-Hydroxymethylfurfural (HMF) is a furanic compound produced in heat-processed foods by nonenzymatic browning reactions. HMF has been demonstrated to be hepato- and nephrotoxic in animals with a link to its metabolite 5-sulfooxymethylfurfural (SMF). To date little is known about either the formation of SMF from ingested HMF or the formation of DNA adducts in animals or human beings.
Methods and results
To assess SMF in vivo formation, we first performed a study in mice treated with high/low doses of oral HMF. We found increased concentrations of SMF in plasma and DNA SMF-adducts in leukocytes, hepatic tissue, and kidneys by means of LC–MS/MS, but no spatial formation in such tissues was observed by MALDI-MS imaging technology due to low sensitivity. In a second experiment, we measured the exposure to HMF in a Spanish preadolescent population. We analyzed the concentration of HMF metabolites (plasma, urine) and measured, for the first time, the presence of SMF in plasma and DNA SMF-adducts in leukocytes.
Conclusion
This study provides the first evidence that oral HMF is readily transformed into SMF in vivo, giving rise to the formation of DNA adducts in a direct relation with HMF intake, both in animals and human beings.