APh, vol. 50(4)https://hdl.handle.net/10481/262612024-03-28T13:59:04Z2024-03-28T13:59:04ZRadioactive immunocomplex formation in a double antibody ria.Olivas Arroyo, C.Moreno Frigols, J.L.https://hdl.handle.net/10481/273942021-06-15T16:41:08ZRadioactive immunocomplex formation in a double antibody ria.
Olivas Arroyo, C.; Moreno Frigols, J.L.
A model has been produced for the kinetic and equilibrium study of antigen-antibody reactions in the radioimmunoassay (RIA) of C-Peptide double antibody. The aim is (1) to characterise the influence of initial concentrations of labelled (M) and unlabelled (Q) antigen and that of the initial concentration of the antibody in solution (P), and (2) to study the binding of the immunocomplex (PM) to the second antibody (J) immobilised on a bead, and the replacement of M by Q in the PMJ immunocomplex. In order to study the effect of such variables, 44 experiments were conducted. The results are in line with the model proposed.; Se ha elaborado un modelo para el estudio de la cinética y equilibrio de las reacciones antígeno-anticuerpo implicadas en el radioinmunoanálisis (RIA) de doble anticuerpo correspondiente al Péptido C. Se pretende caracterizar la influencia de las concentraciones iniciales de antígeno marcado (M) y no marcado (Q) sobre la formación del inmunocomplejo (PM) al segundo anticuerpo (J) inmovilizado sobre una bola. Se realizan 30 experiencias para el estudio del efecto de las variables antes mencionadas. Los resultados obtenidos son concordantes con el modelo propuesto.
Formulation and evaluation of timed delayed capsule device for Chronotherapeutic Delivery of Terbutaline Sulphate.Mahajan, A.N.Pancholi, S.S.https://hdl.handle.net/10481/273932021-06-15T16:41:07ZFormulation and evaluation of timed delayed capsule device for Chronotherapeutic Delivery of Terbutaline Sulphate.
Mahajan, A.N.; Pancholi, S.S.
The aim of the present study was to develop timed delayed capsule device of terbutaline sulphate intended for chronotherapy. A time delayed capsule was prepared by sealing the drug tablet and the expulsion excipient inside the insoluble hard gelatin capsule body with erodible tablet plug. The erodible tablets were prepared by direct compression. Influence of formulation factors such as type of plug material, different plug composition, erodible tablet weight and hardness was investigated to characterize the lag time (t10). The results indicated that drug release from the time delayed capsule exhibited an initial lag period, followed by a stage of rapid drug release. Erodible tablet plugs prepared using higher molecular weight of polyethylene oxide resulted in longer lag times. A good correlation was observed between erodible tablet weight and lag time. In accordance with the chronomodulated therapy of asthma the lag time criterion of 5hrs was satisfied by formulation containing 90mg of WSR N-10 (low molecular weight polyethylene oxide) in the erodible tablet plug.
Evaluation of the anti-wrinkle efficacy of cosmetic formulations with an anti-aging peptide (Argireline®).Ruiz Martínez, María A.Clares Naveros, BeatrizMorales Hernández, María EncarnaciónGallardo Lara, Visitaciónhttps://hdl.handle.net/10481/273922021-06-15T16:41:08ZEvaluation of the anti-wrinkle efficacy of cosmetic formulations with an anti-aging peptide (Argireline®).
Ruiz Martínez, María A.; Clares Naveros, Beatriz; Morales Hernández, María Encarnación; Gallardo Lara, Visitación
The purpose of this research was to evaluate, by means of in vivo studies, the efficacy of new cosmetic active ingredients which effect of botox, called Argireline®), so that width and depth of wrinkles could be established. For this, it is prepared two formulations: an emulsion with an external aqueous phase for normal to dry skin, and a gel for oily skin. We likewise study the water content of the skin after the application of both formulas, as this must be one of the priority functions of facial treatments in general, as well as the level of satisfaction from the subjective point of view, fundamental for patients and their continuation of the treatment.
After the designed tests, it is possible to verify that there is a remarkable diminution of the wrinkles size tested in each patient during the month of treatment. Besides, it is possible to review how the moisturizing capacity has been increased in all cases.
At the end of the visual test, all the volunteers experienced a reduction in the depth of wrinkles, and from the subjective point of view, the appearance and elasticity of the skin were improved. Finally it is possible to conclude that Argireline® (acetyl hexapeptide-8 ) shows a great antiaging capacity in all the cases that have been studied and the tried compounds have increased moisturizing power.
La enfermedad de Chagas en España.Portús Vinyeta, M.https://hdl.handle.net/10481/273912021-06-15T16:41:05ZLa enfermedad de Chagas en España.
Portús Vinyeta, M.
El notable incremento de la inmigración de procedencia Latinoamericana habido en España durante el último lustro, con especial impacto en la población de procedencia boliviana, ha convertido a la enfermedad de Chagas, o tripanosomiasis americana, en un problema de Salud Pública en nuestro país. En el momento actual residen en España casi dos millones y medio de personas oriundas de países endémicos para esta enfermedad que, en ausencia del insecto vector, puede transmitirse por transfusión de sangre, transplantes de tejidos o por vía vertical. En el trabajo se revisa la situación epidemiológica y del conocimiento de esta parasitosis actuales en España; The notable increase in immigration from Latin-American countries to Spain during the last five years, particularly people from Bolivia, has converted Chagas disease or American trypanosomiasis, into a public health problem in Spain. The number of people from countries in which Chagas disease is endemic now living in Spain is estimated to be near two and half million. In the absence of vector species responsible for transmission, the disease may be transmitted by blood transfusion and tissue transplants as well as by vertical transmission. This work reviews the current knowledge and epidemiological situation of this parasitosis in Spain.
Design and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers.Rajan, R.Sheba Rani, N.D.Kajal, G.Sanjoy Kumar, D.Jasmina, K.Arunabha, N.https://hdl.handle.net/10481/273902021-06-15T16:41:04ZDesign and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers.
Rajan, R.; Sheba Rani, N.D.; Kajal, G.; Sanjoy Kumar, D.; Jasmina, K.; Arunabha, N.
The release and permeation studies were carried out for developing transdermal therapeutic systems with chlorpheniramine maleate (CPM). The patches were prepared with eudragit RS-100 and RL-100 with/without polyvinyl pyrrolidone (PVP) and dibutyl phthalate (DBP) in different compositions. Thickness, tensile strength, drug content, moisture content and water absorption studies of the patches were measured. In vitro release/permeation of CPM was studied in modified Keshary-Chien diffusion cell. Chemical enhancers like l-menthol, oleic acid and phospholipon80 were added to compare the release pattern of the drug. The percent release of the drug from matrix patch increased with increase of PVP & DBP but the tensile strength decreased with the increase of DBP & PVP. Experimental release/permeation data of different formulations of the matrix systems are reported. Also the drug-polymer interaction was investigated by ATR-FTIR studies. The discussion was correlated the efficient matrix dispersion patch from suitable eudragit polymers for transdermal antihistamine applications in film device industry.