Ars Pharma 2009, Vol. 50https://hdl.handle.net/10481/262522024-03-19T07:51:49Z2024-03-19T07:51:49ZTécnicas de microencapsulación: una propuesta para microencapsular probióticosMartín Villena, María J.Morales Hernández, María EncarnaciónGallardo Lara, VisitaciónRuiz Martínez, María A.https://hdl.handle.net/10481/274752021-06-15T16:40:49ZTécnicas de microencapsulación: una propuesta para microencapsular probióticos
Martín Villena, María J.; Morales Hernández, María Encarnación; Gallardo Lara, Visitación; Ruiz Martínez, María A.
A la hora de utilizar probióticos, el principal problema que se presenta, es la escasa resistencia de estos a diferentes condiciones ambientales y tecnológicas. Las técnicas de microencapsulación son un buen método para proteger a estos microorganismos, sin embargo no todas las técnicas son apropiadas para los probióticos. En este artículo proponemos la técnica de gelificación interna, que por sus características permite la obtención de un tamaño de partícula adecuado y la supervivencia de los microorganismos.; The main problem when probiotics are used is the low resistance of these to different environmental and technological conditions. The microencapsulation techniques are a good method in order to protect the probiotics, Nevertheless not all techniques of microencapsulation are suitable for probiotics. In this paper, we propose the internal gelification which allows us to obtain a suitable particle size and the survival of the microorganisms.
Actividad antioxidante y polifenoles de las algas marinas halimeda opuntia y halimeda monileVidal-Novoa, A.Silva de Andrade-Wartha, E.R.Oliveira e Silva, A.M. dePavan, R.Lima, A.Fallarero-Linares, A.Batista-González, A.E.Mancini-Filho, J.https://hdl.handle.net/10481/274742021-06-15T16:40:50ZActividad antioxidante y polifenoles de las algas marinas halimeda opuntia y halimeda monile
Vidal-Novoa, A.; Silva de Andrade-Wartha, E.R.; Oliveira e Silva, A.M. de; Pavan, R.; Lima, A.; Fallarero-Linares, A.; Batista-González, A.E.; Mancini-Filho, J.
En este trabajo se estudió la actividad antioxidante de dos especies de algas marinas (H. opuntia y H. monile) mediante el ensayo de atrapamiento de radicales DPPH• y el sistema β-Caroteno-acido linoleico. Adicionalmente a las fracciones de ácidos fenolicos libres, ésteres solubles y ésteres insolubles de ácidos fenólicos se les determinó el contenido en fenoles totales mediante la técnica de Folin-Ciocalteu y posteriormente se identificaron y cuantificaron 8 ácidos fenólicos y cinámicos, resultando el componente mayoritario el ácido salicílico. En los ensayos utilizados se obtuvieron valores altos de actividad antioxidante para las diferentes fracciones. A partir de estos resultados se puede postular que la actividad antioxidante de los extractos polares de estas algas pudiera ser explicada, al menos parcialmente, por la presencia de los ácidos fenólicos y cinámicos. En el caso del alga Halimeda monile, de acuerdo con la literatura consultada, es el primer reporte de la actividad antioxidante.; In this paper, the antioxidant activity displayed by two different green seaweed species (H. opuntia y H. monile) was studied using the β- carotene/ linoleic acid and the DPPH• scavenging.systems as different experimental in vitro antioxidant assessment models. Polar seaweed fractions containing free phenolic acids, soluble esters and insoluble esters of phenolic acids were chemically characterized in terms of their phenolic content and composition. In that direction, 8 phenolic acids were identified and quantified, and salycilic acid was shown to be the majoritary compound on the fractions from both species. In addition, the polar fractions were proved to exert antioxidant activity in the two used experimental systems with considerably low values of CI50. Thus, in view of these findings, the antioxidant activity of these polar Halimeda spp. extracts could be supported and at least partially related to the presence of phenolic acids. In case of Halimeda monile this is, at least to the extend of our knowledge, the first report of such biological activity.
Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming materialLakshmana Prabu, S.Shirwaikar, A.A.Shirwaikar, A.Ravikumar, G.Kumar, A.Jacob, A.https://hdl.handle.net/10481/274732021-06-15T16:40:51ZFormulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material
Lakshmana Prabu, S.; Shirwaikar, A.A.; Shirwaikar, A.; Ravikumar, G.; Kumar, A.; Jacob, A.
Rosin, a natural resin, was used as a hydrophobic matrix material for the controlled release, using diltiazem HCl as model drug. Matrix tablets were prepared by direct compression method using rosin as matrix forming material in different proportions and with different diluent combinations. The tablets prepared were flat faced, retained their shape throughout. The method of preparation of matrix system and its concentration were found to have pronounced effect on the release of diltiazem HCl. The release was found to follow both the first order kinetics and fickian diffusion. The drug delivery was analyzed using the paddle method according to USP XXIII. All the studies were done in phosphate buffer pH 7.4. The matrix tablets were evaluated for its thickness, hardness, friability, weight variation, drug content and invitro release studies. The results suggest that the rosin is useful in developing sustained release matrix tablets, prolong release of water soluble drug for up to 24h. Rosin thus promises considerable utility in the development of oral sustained release drug delivery systems.
Grado de conocimiento sobre el uso de anticonceptivos hormonales en una farmacia comunitaria de ZaragozaPetruta Dimitriu, AnaGarcía-Jiménez, EmilioMartínez Martínez, FernandoMoreno López, Anahttps://hdl.handle.net/10481/274722022-07-08T08:56:59ZGrado de conocimiento sobre el uso de anticonceptivos hormonales en una farmacia comunitaria de Zaragoza
Petruta Dimitriu, Ana; García-Jiménez, Emilio; Martínez Martínez, Fernando; Moreno López, Ana
Introducción: Hoy día es importante conocer bien cómo se emplean los métodos anticonceptivos debido a la aparición de nuevos métodos y formas farmacéuticas para administrarlos, así como saber que hacer ante la aparición de efectos no deseados derivados de su uso.
Objetivos: Determinar el grado de conocimiento de las usuarias de anticonceptivos hormonales (AHO) que acuden a una farmacia comunitaria de Zaragoza.
Método: Estudio observacional, descriptivo, transversal mediante cuestionario ad hoc, administrado a 148 usuarias que acudieron a una farmacia comunitaria de Zaragoza.
Resultados: 48,6 % de las usuarias que respondieron al cuestionario tienen un grado de conocimiento medio, frente a solo 23% de ellas que tienen un grado de conocimiento alto. Sobre el uso de AHO, las usuarias que conocen más acerca de su método, son las que toman la píldora (83,33%), a diferencia de las usuarias que utilizan el anillo vaginal o el parche transdérmico (10,13% y 3,33% respectivamente), [IC-95%, X2=34,898, p<0,001]. No se encontró relación entre el variable conocimiento y las otras variables independientes que se recogían en el perfil de la usuaria (edad, nacionalidad, nivel de estudios, hábito tabáquico, enfermedades concomitantes, y tipo de indicación de la prescripción del AHO).
Conclusiones: Solo una de cada tres usuarias conoce bien como usar el anticonceptivo hormonal que utiliza, no estando influenciado este conocimiento por el perfil de la misma. Es importante diseñar campañas de educación sanitaria dirigidas a mejorar el conocimiento sobre el uso correcto de las nuevas formas farmacéuticas que van apareciendo como métodos anticonceptivos.; Introduction: It is important to know very well each day how one can use a hormonal contraceptive agent due to the introducing of some new contraceptive methods and new pharmaceutical forms of administration, and how one can react when it comes to the appearance of some secondary effects.
Objective: To assess the degree of knowledge among the female users of hormonal contraceptive agents who attended a communitarian pharmacy in Zaragoza, Spain.
Methods: Observational, descriptive, cross-sectional study by means of an administered questionnaire to 148 users who attended a communitarian pharmacy in Zaragoza.
Results: 48.6% of the women who responded to the questionnaire have an average degree of knowledge as opposed with single 23% of them who have a degree of a high knowledge.
In addition, the users who know more about their method are those who are taking the birth control (83.33% of them) in comparison with the users who take the vaginal ring or the transdermal patch (10.13% and 3.33%, respectively) [CI-95%, X2=34,898, p=0.000]. No statistical significance was found between the degree of knowledge and other variables that influence in the profile of the user (age, nationality, studies, smoke habit, concomitant diseases and type of prescription).
Conclusions: Single one of three users knows about the usage of a hormonal contraceptive agent and the degree of knowledge it is not influenced by the user’s profile. It is important to design campaigns of sanitary education about the correct usage and the knowledge of the new contraceptive methods that have been appearing over the last few years.
Development of gastro retentive drug delivery system of cephalexin by using factorial designPrakash Rao, B.Ashok Kottan, NeelimaSnehith, V.S.Ramesh, C.https://hdl.handle.net/10481/274712021-06-15T16:40:52ZDevelopment of gastro retentive drug delivery system of cephalexin by using factorial design
Prakash Rao, B.; Ashok Kottan, Neelima; Snehith, V.S.; Ramesh, C.
The objective of this research work was to formulate and optimize the floating drug delivery system containing cephalexin using 23 factorial design. Floating tablets were prepared by direct compression method incorporating HPMC K4M, xanthan gum, guar gum, sodium bicarbonate and tartaric acid as gas generating agent. The influence of independent variables like, polymer: polymer ratio, polymer type and tartaric acid on floating lag time and cephalexin release profile were studied. The diffusion exponent (n) of Krosmeyer Peppas for optimized formulation was found to be 0.635 which indicates the mechanism of drug release was anomalous transport. Floating lag time of optimized formulation was 1.50 min and remained buoyant for 24 hrs. Optimized formulation was checked for stability at 40ºC / 75% RH which was found to be stable. Scanning electron microscopy study revealed gel formation. FT-IR studies revealed that there was no chemical interaction between cephalexin and other excipients.