@misc{10481/87935,
year = {2017},
url = {https://hdl.handle.net/10481/87935},
abstract = {Aim: Bozepinib is a potent and selective anticancer compound which chemical structure
is made up of a benzofused seven-membered ring and a purine moiety. We previously
demonstrated that the purine fragment does not exert antiproliferative effect per
se. Methodology: A series of 1-(benzenesulfonyl)-4,1-benzoxazepine derivatives were
synthesized in order to study the influence of the benzofused seven-membered ring
in the biological activity of bozepinib by means of antiproliferative, cell cycle and
apoptosis studies. Results & conclusion: Our results show that the methyleneoxy
enamine sulfonyl function is essential in the antitumor activity of the structures and
thus, it is a scaffold suitable for further modification with a view to obtain more
potent antitumor compounds.},
title = {1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds},
doi = {10.4155/fmc-2017-0006},
author = {Cruz López, Olga and Ramirez, Alberto and Navarro Marchal, Saul Abenhamar and García, María A and Marchal Corrales, Juan Antonio and Campos Rosa, Joaquín María and Conejo García, Ana},
}