@misc{10481/87099,
year = {2018},
month = {8},
url = {https://hdl.handle.net/10481/87099},
abstract = {Approximations to the sequences of ancestral proteins can be
derived from the sequences of their modern descendants.
Proteins encoded by such reconstructed sequences can be
prepared in the laboratory and subjected to experimental
scrutiny. These ‘resurrected’ ancestral proteins often display
remarkable properties, reflecting ancestral adaptations to
intra-cellular and extra-cellular environments that differed from
the environments hosting modern/extant proteins. Recent
experimental and computational work has specifically
discussed high stability, substrate and catalytic promiscuity,
conformational flexibility/diversity and altered patterns of
interaction with other sub-cellular components. In this review,
we discuss these remarkable properties as well as recent
attempts to explore their biotechnological and proteinengineering
potential.},
organization = {Departamento de Quimica Fisica, Facultad de Ciencias, University of Granada, 18071 Granada, Spain},
keywords = {Ancestral environments likely differed from the environments hosting modern proteins.},
keywords = {Resurrected ancestral protein often display unusual properties and interactions.},
title = {Biotechnological and protein-engineering implications of ancestral protein resurrection},
doi = {10.1016/j.sbi.2018.02.007},
author = {Risso, Valeria Alejandra and Sánchez Ruiz, José Manuel and Ozkan, S. Banu},
}