@misc{10481/86032,
year = {2023},
month = {12},
url = {https://hdl.handle.net/10481/86032},
abstract = {Background: Findings related to the association between persistent organic pollut-
ants (POPs) and gestational diabetes mellitus (GDM) are inconclusive.
Objectives: To estimate the strength of the association between POP exposure and
GDM in a systematic review with meta-analysis.
Search strategy: MEDLINE, Scopus and Web of Science were searched until July
2023.
Selection criteria: Cohort and case–control studies analysing the association be-
tween POPs and GDM.
Data collection and analysis: We assessed the risk of bias using the Quality in
Prognosis Studies scale (QUIPS). Standardised mean differences were pooled using
random-effect models.
Main results: Sixteen articles including 12 216 participants were selected. The risk of
bias was high in four articles (25%), moderate in 11 (68.75%) and low in one (6.25%).
Small mean difference between GDM cases and controls was observed for PFHpA
(0.26, 95% confidence interval [CI] 0.1–0.35, I2 = 0.0%), PCB180 (0.37, 95% CI 0.19–0.56;
I2 = 25.3%), BDE47 (0.23, 95% CI 0.0–0.45, I2 = 0%), BDE99 (0.36, 95% CI 0.14–0.59;
I2 = 0%), BDE100 (0.42, 95% CI 0.19–0.64; I2 = 0%) and HCB (0.22, 95% CI 0.01–0.42,
I2 = 39.6%). No considerable difference was observed for the rest of POPs.
Conclusion: Small mean differences between GDM cases and controls were ob-
served for some POPs. However, evidence shows mostly moderate quality and results
were heterogeneous. Improved research methodology is needed to assess POPs and
GDM risk.},
organization = {Funding for open access charge: Universidad
de Granada/CBUA},
publisher = {Wiley},
keywords = {Exposure},
keywords = {Gestational diabetes mellitus},
keywords = {Meta-analysis},
keywords = {Persistent organic pollutants},
keywords = {Risk factor},
keywords = {Systematic review},
title = {Persistent organic pollutant exposure as a risk factor of gestational diabetes mellitus: A systematic review and meta-analysis},
doi = {10.1111/1471-0528.17725},
author = {Kouiti, Malak and Castillo-Hermoso, María Ángeles and Youlyouz-Marfak, Ibtissam and Saeed Khan, Khalid and Thangaratinam, Shakila and Olmedo-Requena, Rocío and Zamora, Javier and Jiménez-Moléon, José Juan},
}