@misc{10481/79194,
year = {2022},
month = {12},
url = {https://hdl.handle.net/10481/79194},
abstract = {Excipients are used as vehicles for topical treatments; however, there are not many studies
that evaluate the impact of different excipients themselves. The aim of this research is to assess skin
homeostasis changes in healthy individuals after using water/oil (W/O), oil/water (O/W), Beeler
base, foam and Vaseline excipients. A within-person randomized trial was conducted that included
healthy individuals without previous skin diseases. Skin barrier function parameters, including
stratum corneum hydration (SCH), transepidermal water loss (TEWL), pH, temperature, erythema,
melanin and elasticity (R0, R2, R5 and R7), were measured on the volar forearm before and after
using each excipient. Sixty participants were included in the study, with a mean age of 32 years.
After applying w/o excipient erythema decreased by 25 AU, (p < 0.001) and elasticity increased by
6%. After using the o/w excipient, erythema decreased by 39.36 AU (p < 0.001) and SCH increased
by 6.85 AU (p = 0.009). When applying the Beeler excipient, erythema decreased by 41.23 AU
(p < 0.001) and SCH increased by 15.92 AU (p < 0.001). Foam and Vaseline decreased TEWL and
erythema. Excipients have a different impact on skin barrier function. Knowing the effect of excipients
on the skin could help to develop new topical treatments and help specialists to choose the best
excipient according to the pathology},
publisher = {MDPI},
keywords = {Excipient},
keywords = {Topical drugs},
keywords = {Vaseline},
keywords = {Petrolatum jelly},
keywords = {W/O emulsion},
keywords = {O/W emulsion},
keywords = {Foam},
keywords = {Beeler base},
title = {The Assessment of Skin Homeostasis Changes after Using Different Types of Excipients in Healthy Individuals},
doi = {10.3390/ijerph192416678},
author = {Ordóñez Toro, Abraham and Montero Vílchez, Trinidad and Muñoz Baeza, José and Sanabria de la Torre, Raquel and Buendía Eisman, Agustín and Arias Santiago, Salvador Antonio},
}