@misc{10481/78417,
year = {2022},
month = {11},
url = {https://hdl.handle.net/10481/78417},
abstract = {Participation in randomised clinical trials (RCTs) entails taking part in the discovery of
effects of health care interventions. The question of whether participants’ outcomes are different
to those of non-participants remains controversial. This umbrella review was aimed at assessing
whether there are health benefits of participation in RCTs, compared to non-participation. After
prospective registration (PROSPERO CRD42021287812), we searched the Medline, Scopus,Web of
Science and Cochrane Library databases from inception to June 2022 to identify relevant systematic
reviews with or without meta-analyses. Data extraction and study quality assessment (AMSTAR-2)
were performed by two independent reviewers. Of 914 records, six systematic reviews summarising
380 comparisons of RCT participants with non-participants met the inclusion criteria. In two reviews,
the majority of comparisons were in favour of participation in RCTs. Of the total of comparisons,
69 (18.7%) were in favour of participation, reporting statistically significant better outcomes for
patients treated within RCTs, 264 (71.7%) comparisons were not statistically significant, and 35 (9.5%)
comparisons were in favour of non-participation. None of the reviews found a harmful effect of
participation in RCTs. Our findings suggest that taking part in RCTs may be beneficial compared
to non-participation.},
organization = {Ministry of Science and Innovation, Instituto de Salud Carlos III},
organization = {FEDER co-funding from European Union	PI20/01532},
organization = {Centro de Investigacion Biomedica en Red-Epidemiologia y Salud Publica	CIBERESP/CB06/02/1014},
publisher = {MDPI},
keywords = {Participation},
keywords = {Non-participants},
keywords = {Systematic reviews},
keywords = {Umbrella review},
keywords = {Health changes},
keywords = {Randomised controlled trial},
title = {Benefits of Participation in Clinical Trials: An Umbrella Review},
doi = {10.3390/ijerph192215368},
author = {Bouzalmate Hajjaj, Amira and Massó Guijarro, Paloma and Saeed Khan, Khalid and Bueno Cavanillas, Aurora and Cano Ibáñez, Naomi},
}