@misc{10481/52909,
year = {2018},
url = {http://hdl.handle.net/10481/52909},
abstract = {Background: The inner structure of trabecular bone is a result of structural optimisation
provided by remodeling processes. Changes in hormonal status related to menopause
cause bone tissue loss and micro-architectural deterioration with a consequent
susceptibility to fracture. Accumulation of micro-damage in bone, as a function of the
rate of production and rate of repair, underlies the development of stress fractures,
increasing fragility associated to age and osteoporosis, especially in transmenopausal
women. Patients and Methods: Quasi-static and nano-dynamic mechanical
characterisation were undertaken in trabecular bone from femoral neck biopsies of
postmenopausal women. AFM complementary studies were performed to determine
nano-roughness (SRa) and the fibrils width of collagen. Nanoindentations were used to
quantify transmenopausal changes in intrinsic mechanical properties of trabecular bone:
hardness (Hi), modulus of Young (Ei), complex modulus (E*), tan delta (δ), storage
modulus (E') and loss modulus (E"). Results: As result of the quasi-static measurements,
0.149 (0.036) GPa and 2.95 (0.73) GPa of Hi and Ei were obtained, respectively. As result
of the nano-dynamic measurements, 17.94 (3.15), 0.62 (0.10), 13.79 (3.21 and 6.39 (1.28)
GPa of E*, tan (δ), E' and E" were achieved, respectively. 101.07 SRa and 831.28 nm of
fibrils width were additionally obtained. Conclusion: This study poses a first approach to
the measurement of bone quality in postmenopausal trabecular bone by combining quasistatic,
nano-DMA analysis and tribology of dentin surface through AFM characterization},
organization = {Project MAT2017-85999-P supported by the Ministry of Economy and Competitiveness
(MINECO) and European Regional Development Fund (FEDER).},
keywords = {Trabecular bone},
keywords = {static},
keywords = {dynamic},
keywords = {mechanic},
keywords = {menopause},
title = {Assessing bone quality through mechanical properties in postmenopausal trabecular bone.},
doi = {10.1016/j.injury.2018.07.035.},
author = {Toledano Pérez, Manuel and Toledano Osorio, Manuel and Guerado, Enrique and Caso, Enrique and Osorio Ruiz, María Estrella and Osorio Ruiz, Raquel},
}