@misc{10481/30946,
year = {2012},
url = {http://hdl.handle.net/10481/30946},
abstract = {Introduction

Functional imaging studies of addiction following protracted abstinence have not been systematically conducted to look at the associations between severity of use of different drugs and brain dysfunction. Findings from such studies may be relevant to implement specific interventions for treatment. The aim of this study was to examine the association between resting-state regional brain metabolism (measured with 18F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and the severity of use of cocaine, heroin, alcohol, MDMA and cannabis in a sample of polysubstance users with prolonged abstinence from all drugs used.},
abstract = {Methods

Our sample consisted of 49 polysubstance users enrolled in residential treatment. We conducted correlation analyses between estimates of use of cocaine, heroin, alcohol, MDMA and cannabis and brain metabolism (BM) (using Statistical Parametric Mapping voxel-based (VB) whole-brain analyses). In all correlation analyses conducted for each of the drugs we controlled for the co-abuse of the other drugs used.},
abstract = {Results

The analysis showed significant negative correlations between severity of heroin, alcohol, MDMA and cannabis use and BM in the dorsolateral prefrontal cortex (DLPFC) and temporal cortex. Alcohol use was further associated with lower metabolism in frontal premotor cortex and putamen, and stimulants use with parietal cortex.},
abstract = {Conclusions

Duration of use of different drugs negatively correlated with overlapping regions in the DLPFC, whereas severity of cocaine, heroin and alcohol use selectively impact parietal, temporal, and frontal-premotor/basal ganglia regions respectively. The knowledge of these associations could be useful in the clinical practice since different brain alterations have been associated with different patterns of execution that may affect the rehabilitation of these patients.},
organization = {This study has been supported with funds from the SEJ2006-08278 project from the Spanish Ministry of Education and Science, the P07-HUM-03089 project from the Council of Science and Innovation. Laura Moreno-López is supported by the FPU grant (AP2007-03583) from the Spanish Ministry of Science and Innovation.},
publisher = {Public Library of Science (PLOS)},
keywords = {Alcohols},
keywords = {Cannabis},
keywords = {Cocaine},
keywords = {Drug metabolism},
keywords = {Drug users},
keywords = {Heroin},
keywords = {Neuroimaging},
keywords = {Positron emission tomography},
title = {Neural Correlates of the Severity of Cocaine, Heroin, Alcohol, MDMA and Cannabis Use in Polysubstance Abusers: A Resting-PET Brain Metabolism Study},
author = {Moreno-López, Laura and Stamatakis, Emmanuel A. and Fernández-Serrano, María José and Gómez Río, Manuel and Rodríguez Fernández, Antonio and Pérez García, Miguel and Verdejo García, Antonio Javier},
}