@misc{10481/27416,
year = {2010},
url = {http://hdl.handle.net/10481/27416},
abstract = {The aim of this study was to develop a single combined once-daily sustained release
microencapsulated dosage form of Allopurinol and Nimesulide using Ethyl cellulose as release
controlling factor and to evaluate drug release parameters as per various release kinetic models. In
order to achieve required sustained release profile, microparticles were prepared using coacervation
thermal change technique. The formulated microparticles were also characterized by physical and
chemical parameters and results were found in acceptable limits. Different dissolution models were
applied to drug release data in order to evaluate release mechanisms and kinetics. The drug release data fit well to the Higuchi expression. Drug release mechanism was found as a complex anomalous one.},
publisher = {Universidad de Granada, Facultad de Farmacia},
keywords = {Ibuprofen},
keywords = {Sustained release},
keywords = {Hydrophilic matrix},
keywords = {HPMC},
keywords = {Direct compression},
title = {Development of a single combined microencapsulated formulation of allopurinol and nimesulide and investigation of their release behaviours},
author = {Khan, S.A. and Ahmad, M. and Murtaza, G. and Aamir, M.N. and Madni, A. and Kousar, R. and Minhas, U.},
}